Apolipoprotein A-1 | Apo AI
- Catalog Number: A70101
- Price: $285
Apo A1 standard also available
Apo AI is primarily found in high density lipoprotein (HDL) particle. It serves the function of preventing the accumulation of cholesterol loaded macrophages which deposit on the arterial wall as foam cells. This is the prominent early feature of atherosclerotic lesion formation ultimately resulting in atherosclerosis. Apo AI, is a single polypeptide with a molecular weight of 28 Kd. Its primary function is to activate LCAT within the HDL complex, which catalyzes the esterification of cholesterol. This results in a more soluble cholesterol-HDL complex which increases the cholesterol transport capacity of the HDL particle for subsequent removal by the liver. Apo AI is therefore a convenient marker for assessing the cholesterol clearing capacity of the blood, and studies have clearly indicated that it is a better discriminator of angiographically documented coronary artery disease than HDL cholesterol.
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